Persistent polyclonal B-cell lymphocytosis is a rare type of lymphocytosis that needs to be distinguished from more serious lymphoproliferative disorders.
Features:
(1) persistent lymphocytosis with binucleated circulating lymphocytes
(2) flow cytometry shows these cells to be polyclonal B-cells
(3) cytogenetic and molecular methods negative for clonal populations
(4) cytogenetics may show +i(3q) and/or premature chromosome condensation
Clinical findings:
(1) often female gender
(2) usually the patient is a smoker
(3) elevated serum IgM immunoglobulins
(4) HLA-DR7 antigen
(5) other family members may be affected.
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