Localized granulomatous lymphangitis can result in chronic penile and scrotal edema.
Clinical features:
(1) The patient presents with a relatively painless chronic edema of the scrotum and/or penis.
(2) Some patients may develop skin ulceration and/or inguinal lymphadenopathy.
(3) A biopsy may show noncaseating sarcoid-like granulomas:
(3a) in and around lymphatic channels
(3b) in the dermis or subcutaneum
Causes may include:
(1) lymphogranuloma venereum (LGV)
(2) granuloma inguinale
(3) Crohn’s disease
(4) Milroy’s disease
(5) trauma
(6) Melkersson-Rosenthal syndrome
(7) possibly sarcoidosis
