Johnson et al reported the predictive value of the Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score in pediatric patients with cerebral malaria. The authors are from Ohio State University, Nationwide Children's Hospital, Children's Hospital of Philadelphia, University of Pennsylvania, Universidad Nacional Autonoma de Mexico, Michigan State University and University of Malawi.
Patient selection: pediatric patient with cerebral malaria
Cerebral malaria has a fatality rate of up to 40%. Many patients are less than 5 years of age.
Mortality is increased with multi-organ failure.
Parameters:
(1) PELOD-2 score on admission
Outcome
Admission PELOD-2 Score
survivor
3 to 6 (median 4)
non-survivor
5 to 10 (median 6.5)
A PELOD-2 score > 5.5 had the maximum Youden score.
Other prognostic factors:
(1) age in months (survivors 39 to 79 months; non-survivors 25-55 months)
(2) PELOD-2 score without neurologic component
(3) PELOD-2 subcomponents for neurologic and cardiovascular organ dysfunction
(4) serum lactate >= 5 mmol/L
Performance of PELOD-2 score:
• The area under the ROC curve is 0.75.
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