Brogan et al reported the Pediatric Glucocorticoid Toxicity Index (pGTI). This is based on the Glucocorticoid Toxicity Index (GTI). The authors are from multiple institutions in England, the United States and Canada.
Patient selection: <= 18 years old on glucocorticoids
Parameters:
(1) acne
(2) easy bruising
(3) hirsutism
(4) striae and/atrophy
Parameter
Finding
Points
acne
moderate acne to none
-12
moderate acne to minor
-8
minor acne to none
-4
no change
0
no acne to mild
4
minor acne to moderate
8
no acne to moderate
12
easy bruising
moderate easy bruising to none
-11
moderate easy bruising to minor
-9
minor easy bruising to none
-2
no change
0
no easy bruising to minor
2
minor easy bruising to moderate
9
no easy bruising to moderate
11
hirsutism
moderate hirsutism to none
-16
moderate hirsutism to minor
-11
minor hirsutism to mone
-5
no change
0
no hirsutism to minor
5
minor hirsutism to moderate
11
no hirsutism to moderate
16
striae and/or atrophy
moderate to none
-33
moderate to minor
-23
minor to none
-10
no change
0
ho striae or atrophy to minor
10
minor to moderate
23
no striae or atrophy to moderate
33
subscore for skin =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: -72
• maximum score: 72
• The higher the score the greater the skin toxicity.
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