Kidney stones are relatively uncommon in children. A pediatric patient with Cushing's disease may present with nephrolithiasis. Kidney stones are relatively common in adults with Cushing's disease.

Patient selection: child with nephrolithiasis


Predisposing factors for stone development: hypercalcuria secondary to increased bone resorption


Other manifestations may include:

(1) obesity

(2) hypertension

(3) diabetes

(4) striae

(5) hirsutism

(6) reduced height for age


Laboratory findings:

(1) elevated urine free cortisol

(2) elevated urinary calcium to creatinine ratio

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