The pattern of a diabetic patient's response to intravenous glucagon gives insight into the insulin secretory reserve. The authors are from the Mayo Cliinic.
Patient selection: diabetic
Parameters:
(1) basal serum concentration of C-peptide in pmol/mL
(2) serum concentration of C-peptide at 6 minutes after intravenous glucagon (1 mg)
increase in C-peptide after glucagon =
= (C-peptide after glucagon) - (basal C-peptide)
Basal C-Peptide
Increase in C-Peptide
Pattern
< 0.07
< 0.07
A
< 0.07
0.07 to 0.16
C
< 0.07
>= 0.17
G
0.07 to 0.16
< 0.07
B
0.07 to 0.16
0.07 to 0.16
F
0.07 to 0.16
>= 0.17
E
>= 0.17
< 0.07
H
> = 0.17
0.07 to 0.16
I
>= 0.17
>= 0.17
D
Patterns A and B are indicative of insulin-dependent diabetes.
The other patterns are indicative of non-insulin-dependent diabetes.
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