Certain patients are at risk for developing riboflavin (vitamin B2) deficiency or for maintaining low vitamin levels. A patient with one or more of these findings should be considered for a further evaluation of riboflavin status.



(1) elderly

(2) chronic alcohol abuse

(3) presence of other vitamin deficiencies


Decreased intake:

(1) starvation, negative nitrogen balance or malnutrition

(2) anorexia

(3) diet low in dairy products, green leafy vegetables, vitamin supplements, riboflavin enriched products, and animal protein

(4) lactose intolerance (due to avoidance of dairy products)


Decreased absorption:

(1) malabsorption

(2) chronic diarrhea


Increased utilization or loss:

(1) heavy exercise

(2) heat stress

(3) systemic infection

(4) drugs (antibiotics, phenothiazines, barbiturates, chlorpromazine, tricyclic antidepressants)

(5) inborn errors of metabolism affecting formation of flavoproteins

(6) phototherapy in newborn infants


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