Ehrenreich and Chung reported pathologic features of idiopathic membranous nephropathy in 1968.
Patient selection: idiopathic membranous nephropathy
Parameters:
(1) histologic appearance on light microscopy
(2) changes on electron microscopy
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Light Microscopy
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Electron Microscopy
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Stage
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normal glomeruli
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subepithelial immune complex deposits
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I
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heterogenous thickening of GBM with formation of spikes
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subepithelial immune complex deposits
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II
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thickening of GBM
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immune complex deposits are subepithelial and/or within the GBM
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III
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greater thickening of GBM
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immune complexes within GBM
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IV
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where:
• GBM = glomerular basement membrane
