Advanced maternal age (AMA) may be associated with a number of pathologic changes in the placenta.
"Regular: advanced maternal age: 35 to 40 years of age
"Very" advanced maternal age: > 40 years of age
Pathologic changes may include:
(1) meconium deposition
(2) chorangiosis (> 10 capillaries per terminal villus)
(3) acute chorioamnionitis
(4) fetal vascular malperfusion (with occlusive or nonocclusive thrombi and/or avascular villi)
(5) delayed villous maturation
(6) chronic deciduitis
Problems that may be more common in older women and which may have an adverse effect on the pregnancy:
(1) obesity
(2) diabetes
(3) hypertension
(4) other comorbid conditions
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Specialty: Obstetrics & Gynecology
