The precise cause of Fuchs Uveitis Syndrome is uncertain. Finding the cause may help to identify an effective therapy since it may respond poorly to corticosteroids.
The current theory is a persistent infection that may be congenital or acquired.
Infections that have been implicated in Fuchs Uveitis Syndrome:
(1) rubella
(2) Herpes simplex virus (HSV)
(3) cytomegalovirus (CMV)
(4) varicella-zoster virus (VZV)
(5) toxoplasmosis
These have been implicated based on antibodies in the vitreous fluid and PCR.
Other conditions that may be with Fuchs Uveitis Syndrome include:
(1) retinitis pigmentosa
(2) progressive hemifacial atrophy
(3) Coats disease
(4) Horner's syndrome
(5) autoimmunity
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