The precise cause of Fuchs Uveitis Syndrome is uncertain. Finding the cause may help to identify an effective therapy since it may respond poorly to corticosteroids.

The current theory is a persistent infection that may be congenital or acquired.


Infections that have been implicated in Fuchs Uveitis Syndrome:

(1) rubella

(2) Herpes simplex virus (HSV)

(3) cytomegalovirus (CMV)

(4) varicella-zoster virus (VZV)

(5) toxoplasmosis


These have been implicated based on antibodies in the vitreous fluid and PCR.


Other conditions that may be with Fuchs Uveitis Syndrome include:

(1) retinitis pigmentosa

(2) progressive hemifacial atrophy

(3) Coats disease

(4) Horner's syndrome

(5) autoimmunity

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