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Parkinsonism from Exposure to MPTP Contaminating a Synthetic Meperidine Analogue

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

MPTP and related compounds can destroy dopamine-containing neurons in the substantia nigra. Patients using a synthetic designer drug designed to be an analogue to meperidine developed a Parkinson-like disorder. MPTP was found as a byproduct of the synthesis.

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