Acute febrile neutrophilic dermatosis (Sweet's Syndrome) can occur as a paraneoplastic syndrome.

Cancers associated with paraneoplastic Sweet's syndrome:

(1) acute myelogenous leukemia)

(2) renal cell carcinoma

(3) carcinoma of the urinary bladder

(4) breast cancer

(5) cancers of the GI tract

(7) malignant lymphoma


Features of paraneoplastic Sweet's syndrome:

(1) The patient has an underlying malignancy.

(2) A biopsy meets the histologic criteria of Sweet's syndrome.

(3) It may improve after cancer therapy and relapse with recurrence.


Differential diagnosis:

(1) drug-induced Sweet's syndrome

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