A patient with malignancy may develop a peripheral sensorimotor neuropathy.


Tumors causing sensorimotor neuropathy include:

(1) malignant lymphoma

(2) lung carcinoma

(3) malignant melanoma

(4) other malignancy


Features of paraneoplastic sensorimotor neuropathy:

(1) The neuropathy may be subclinical but detectable using electrophysiologic techniques.

(2) The onset may precede diagnosis of the the underlying tumor.

(3) The likelihood of a neuropathy develops increases with disease duration.

(4) Symptoms may be progressive, relapsing or remitting.

(5) Anti-Hu antibodies or other antibodies may be present in the serum.


The differential diagnosis includes:

(1) neuropathy related to chemotherapy

(2) neuropathy related to underlying diabetes or other metabolic disease

(3) neuropathy associated with mechanical compression


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