Tumors causing sensorimotor neuropathy include:
(1) malignant lymphoma
(2) lung carcinoma
(3) malignant melanoma
(4) other malignancy
Features of paraneoplastic sensorimotor neuropathy:
(1) The neuropathy may be subclinical but detectable using electrophysiologic techniques.
(2) The onset may precede diagnosis of the the underlying tumor.
(3) The likelihood of a neuropathy develops increases with disease duration.
(4) Symptoms may be progressive, relapsing or remitting.
(5) Anti-Hu antibodies or other antibodies may be present in the serum.
The differential diagnosis includes:
(1) neuropathy related to chemotherapy
(2) neuropathy related to underlying diabetes or other metabolic disease
(3) neuropathy associated with mechanical compression
