Pyoderma gangrenosum (PG) can occur as a paraneoplastic disorder.


Clinical features:

(1) The appearance of the pyoderma gangrenosum is temporally related to the onset of the underlying malignancy. It may appear before the tumor is diagnosed but the interval should be limited.

(2) There is no past history of pyoderma gangrenosum.

(3) The activity of the pyoderma should move in tandem with the malignancy, improving during a remission and worsening with disease progression.


The most common malignancies associated with paraneoplastic PG are hematologic:

(1) acute leukemia

(2) myelodysplastic syndrome

(3) myeloproliferative disorder

(4) monoclonal gammopathy

(5) Hodgkin's disease


Other tumors associated with paraneoplastic PG:

(1) gastric adenocarcinoma

(2) other adenocarcinoma of the gastrointestinal tract

(3) breast carcinoma


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