Erythema of the palms may represent a paraneoplastic finding.
Possible mechanism: angiogenic factors causing dilated blood vessels, possibly VEGF
Occurrence:
(1) brain tumors
(2) lung cancer
(3) gastric adenocarcinoma
(4) Hodgkin's disease
Clinical features:
(1) local or diffuse palmar redness (thenar, hypothenar, fingertips)
(2) presence of a malignant neoplasm
(3) onset of palmar erythema just before or after the diagnosis of the tumor
(4) reduced erythema with tumor control and worsening with tumor progression (intensity is parallel to tumor burden)
(5) no other diagnosis explains the erythema better
