Multicentric Reticulohistiocytosis (MRH) can occur as a paraneoplastic disorder. This has to be distinguished from the two conditions occurring independently.


Features of Multicentric Reticulohistiocytosis (MRH):

(1) papulonodular skin lesions

(2) erosive polyarthritis

(3) characteristic histology in biopsy of skin lesions or synovium with histiocytes and multinucleated giant cells


Tumors associated with MRH include:

(1) breast cancer

(2) lung cancer

(3) colon cancer

(4) stomach cancer

(5) ovarian cancer

(6) cervical cancer

(7) pancreatic adenocarcinoma

(8) malignant melanoma


MRH can be viewed as paraneoplastic if:

(1) The MRH appeared in a period from shortly before to after the diagnosis of the cancer.

(2) MRH regresses on treatment of the cancer (excluding a direct effect of any chemotherapeutic agents on the MRH).

(3) MRH becomes more severe if the cancer progresses.


If MRH is paraneoplastic then treatment of the cancer can be important for managing the MRH.


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