Guillain-Barre Syndrome (GBS) can occur as a paraneoplastic syndrome. The antibody causing the immune-mediated polyneuropathy may be correlated with tumor activity.


Malignant tumors associated with GBS:

(1) small cell carcinoma of the lung

(2) Hodgkin's disease or malignant lymphoma

(3) lymphocytic or lymphoblastic leukemia, including hairy cell

(4) visceral adenocarcinomas



(1) The onset of GBS may precede the diagnosis of cancer or may herald a relapse.

(2) The presence of an underlying cancer is associated with a worse neurologic progrnosis.

(3) The patient may respond to plasma exchange, intravenous immunoglobulin and/or therapy of the underlying tumor.


Differential diagnosis:

(1) post-infectious GBS in a patient with cancer


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