Paraneoplastic autoimmune multiorgan syndrome (PAMS) is a systemic disorder associated with cancer. It includes paraneoplastic pemphigus with involvement of sites other than skin (paranoeplastic pemphigus plus).
Type of paraneoplastic syndrome: autoimmune
Mechanisms of cell injury:
(1) autoantibodies to bound antigens with acantholysis
(2) circulating immune complexes
(3) cell-mediated autoimmunity with a lichenoid inflammatory infiltrate
Sites of involvement:
(1) skin
(1a) paraneoplastic pemphigus (PNP)
(1b) bullous pemphigoid
(1c) erythema multiforme
(1d) lichen planus
(1e) graft-vs-host disease like
(2) mucosal surfaces
(2a) mouth
(2b) pharynx
(2c) conjunctiva
(2d) genitalia
(3) respiratory system
(3a) larynx, trachea and bronchus with sloughing of mucosa (which can result in bronchial plugs)
(3b) bronchiolitis obliterans
(4) glomeruli
(5) urinary bladder
(6) muscle (myositis)
(7) central nervous system
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