A patient with severe anorexia may develop pancytopenia.

Patient selection: severe anorexia nervosa


The pancytopenia is probably multifactorial, including protein malnutrition and deficiency in vitamins and micronutrients.


Clinical and laboratory findings - any combination of:

(1) anemia

(2) neutropenia, which may be associated with sepsis or other infection

(3) thrombocytopenia, with purpura and bleeding


A bone marrow biopsy shows:

(1) gelatinous transformation or fatty infiltration

(2) hypoplasia without dysplasia


The diagnosis is supported by:

(1) exclusion of other causes of pancytopenia

(2) reversal on adequate nutritional replacement

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