An HIV-positive patient being treated with didanosine is at risk for acute pancreatitis, especially if certain risk factors are present.


Patient selection: HIV-positive and being treated with didanosine


Risk factors for acute pancreatitis:

(1) AIDS or absolute CD4 count < 200 per µL

(2) dose of didanosine > 9.6 mg per kg per day

(3) hyperlipidemia

(4) hypercalcemia

(5) therapy with additional medications associated with pancreatitis including pentamidine, ribavirin and stavudine

(6) history of pancreatitis

(7) ethanol abuse


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