Women with a BRCA mutation are at increased risk for developing serous carcinomas of the fallopian tube. The p53 signature can identify "hot spots" in the tubal epithelium that may be prone to develop a serous carcinoma.
The common site for early serous carcinomas of the fallopian tube is in the fimbria. A tubal intraepithelial carcinoma (TIC) is an early stage in disease progression.
p53 staining tends to target secretory cells in the fimbria with DNA damage.
Criteria of a p53 signature:
(1) strong p53 immunoreactivity of nuclei
(2) staining of a row of 12 or more consecutive secretory cell nuclei
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