Exposure to ozone can rarely result in neurotoxicity.

Ozone is an oxidizing agent that can react with molecules to cause oxidation or peroxidation.


Sources of ozone exposure: environmental smog, industrial, medical therapy with ozone


Clinical features of ozone-induced encephalopathy:

(1) exposure to ozone

(2) neurologic findings occurring during or soon after ozone exposure (see below)

(3) reversal or improvement after ozone exposure discontinued

(4) exclusion of other causes


Neurologic findings may include:

(1) loss of consciousness

(2) visual impairment, which may include cortical blindness

(3) antegrade amnesia

(4) restlessness or agitation

(5) headache

(6) motor dysphasia

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