The Oxford Classification of IgA Nephropathy was developed at consensus meetings held in Oxford, England, in 2005 and 2008. The goal was to develop a standard way of reporting findings seen on kidney biopsy from a patient with IgA nephropathy.
Parameters:
(1) mesangial hypercellularity (M)
(2) endocapillary hypercellularity (E)
(3) segmental glomerulosclerosis (S)
(4) tubular atrophy or interstitial fibrosis (T), as percent of cortical area
Parameter
Finding
Code
mesangial hypercellularity
<= 50% of mesangial areas show increased hypercellularity (mild or greater)
M0
> 50% of mesangial areas
M1
endocapillary hypercellularity
absent
E0
present
E1
segmental glomerulosclerosis
absent
S0
present
S1
tubular atrophy or interstitial fibrosis
<= 25% (absent to mild)
T0
26 to 50% (moderate)
T1
> 50% (severe)
T2
where:
• Less than 4 mesangial cells per mesangial area in the most cellular area is normal (avoiding mesangial areas adjacent to the vascular stalk or central mesangial areas). If more than 50% glomeruli show areas of increased cellularity then the biopsy is designated M1.
• The full histologic definitions are given in Table 2, Roberts et al (2009).
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