Osmotic Fragility


Erythrocytes, when placed in saline solutions of varying concentrations, may hemolyze, the degree of which depends on the concentration of the salt and the characteristics of the erythrocytes. The hemolysis occurs when the erythrocytes swell beyond the structural capacity of the red cell membrane. Spherocytes lyze at higher salt concentrations than normal cells, while target cells lyze at lower concentrations than normal cells. Incubation cause erythrocytes to become more spherical in shape, causing RBCs to lyze at a higher salt concentration than fresh RBCs.

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