Oral Verruciform Xanthoma (OVX) is a benign lesion of the oral mucosa.


Clinical appearance:

(1) “normal”, pale, yellowish or reddish

(2) rough surface with variable hyperkeratosis

(3) sessile or pedunculated

(4) diameter up to 1.5 cm



(1) palate

(2) tongue

(3) buccal mucosa

(4) gingiva


The diagnosis is made by histologic exam of a biopsy or resected specimen.


Histologic features:

(1) large number of xanthoma cells in the submucosa (PAS positive, CD68 positive)

(2) exclusion of malignancy or alternative diagnosis


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