Fordyce spots can be found in the mouth or on the genitals of many adults.

Clinical features:

(1) multiple small yellowish-white papules on the buccal mucosa or inner surface of the lips

(2) asymptomatic


Histologic findings:

(1) sebaceous gland hyperplasia


Occurrence of Fordyce spots on the lower gingiva and vestibular oral mucosa can be seen with hereditary non-polyposis colorectal cancer center (HNPCC).


Differential diagnosis:

(1) HPV infection


Therapy may include:

(1) isotretinoin

(2) electrodesiccation

(3) CO2 laser

(4) bichloracetic acid

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