A patient with hereditary epidermolysis bullosa (EB) experiences increased fragility of skin and other tissues. A number of problems may affect the teeth and oral mucosa of these patients. Oral and dental changes may be found in all forms of epidermolysis bullosa but are most often seen in generalized juvenile EB (JEB) and recessive-dystrophic epidermolysis bullosa of the Hallopeau-Siemens subtype (RDEB-HS).