A number of oral and dental changes occur in patients with acromegaly. A dentist may be the first clinician to diagnose the patient.

Oral and dental changes that can occur in acromegaly:

(1) malocclusion, including apertognathia (premature occlusion of the posterior teeth), crossbite and open-bite

(2) mandibular prognathism

(3) temporomandibular joint disorder

(4) macroglossia

(5) increased dental spacing (diastema)

(6) an increase in the size of the lips

(7) hypertrophy of palatal tissue with obstructive sleep apnea

(8) taurodontism

(9) marked nasolabial folds

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