Civino et al reported the ONCOREUM score for distinguishing pediatric patients with childhood cancer with arthropathy from those with juvenile idiopathic arthritis (JIA). The authors are from multiple institutions in Italy.
Patient selection: pediatric patient with articular symptoms
Parameters:
(1) limb joint pain
(2) weight loss
(3) thrombocytopenia
(4) morning stiffness
(5) joint swelling
(6) small hand joint involvement
(7) monoarticular involvement
(8) hip involvement
(9) sex
Parameter
Finding
Points
limb joint pain
no
0
yes
8.4
weight loss
no
0
yes
4.7
thrombocytopenia
no
0
yes
5.1
morning stiffness
no
0
yes
-5.2
joint swelling
no
0
yes
-3.7
small hand joint involvement
no
0
yes
-5.0
monoarticular involvement
no
0
yes
4.1
hip involvement
no
0
yes
2.4
sex
female
0
male
1.2
total score =
= SUM(points for all of the parameters) - 4.1
Interpretation:
• minimum score: -18
• maximum score: 21.8
• A score >= -6 indicates a higher risk of childhood cancer with arthropathy.
• A score < -6 indicates a higher risk of JIA.
Performance:
• The area under the ROC curve is reported as 0.97.
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