Pankratz et al developed risk scores for development of mild cognitive impairment (MCI) in older adults. One set of scores is for males and another for females. The authors are from the Mayo Clinic with the study performed in Olmsted County, Minnesota.
Patient selection: adult female from 70 to 89 years of age
Outcome: mild cognitive impairment
Parameters:
(1) education in years
(2) self-reported memory concerns
(3) ever diagnosed with alcohol problem
(4) history of stroke
(5) diabetes AND age at assessment
(6) history of atrial fibrillation
(7) current smoker
(8) midlife dyslipidemia
(9) definite or probable diabetes in midlife
(10) midlife hypertension
Parameter
Finding
Points
education in years
<= 12 years
2
> 12 years
0
self-reported memory concern
no
0
yes
2
alcohol problem
no
0
yes
3
history of stroke
no
0
yes
1
diabetes and age
no diabetes
0
diabetes and < 75 years
5
diabetes and 75 to 84
2
diabetes and 85 to 89
0
history of atrial fibrillation
no
0
yes
1
current smoker
no
0
yes
3
midlife dysplipidemia
no
0
yes
2
diabetes midlife
no
0
yes
2
midlife hypertension
no
0
ye
1
total score =
= SUM(points for all 8 parameters)
Interpretation:
• minimum score: 0
• maximum score: 22
Score
Quartile
Median MCI-free Survival
0 to 2
1
90 years
3
2
89 years
4
3
85.5 years
>= 5
4
85.5 years
Performance:
• The area under the ROC curve is 0.58 (poor).
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