The diagnosis of an attack in multiple sclerosis should be supported by the presence of some objective evidence.

Patient selection: The patient has a sign or symptom indicative of an anatomic region in the CNS.


Objective evidence involves an abnormality at that region identified on:

(1) the neurological examination

(2) imaging (MRI or optical coherence tomography), or

(3) neurophysiological testing (visual evoked potentials)


Caution should be exercised in accepting symptoms accompanied only by patient-reported subjective alteration as evidence of a current or previous attack.

To read more or access our algorithms and calculators, please log in or register.