Behrendt et al reported the OAC3-PAD score to identify a patient with peripheral arterial disease who is at risk for a major bleeding. The authors are from multiple institutions in Europe.
OAC3-PAD is based on the first letter of the 8 parameters, with 3 starting with "c".
Patient selection: symptomaatic peripheral arterial disease on anticoagulation
Outcome: major bleeding within 1 year of index hospitalization
Parameters:
(1) oral anticoagulation before index hospitalisation
(2) age in years
(3) chronic limb threatening ischaemia
(4) congestive heart failure
(5) chronic kidney disease
(6) prior episode of bleeding
(7) anemia
(8) dementia
Parameter
Finding
Points
oral anticoagulation before
no
0
yes
5
age in years
<= 80 years
0
> 80 years
2
chronic limb threatening ischemia
no
0
yes
4
congestive heart failure
no
0
yes
3
chronic kidney disease
none
0
mild or moderate
0
severe
3
prior bleeding
no
0
yes
5
anemia
no
0
yes
8
dementia
no
0
yes
3
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 33
Total Score
Major Bleeding
0
1.3%
1 to 4
1.8%
5 to 9
2.6%
10 to 33
6.4%
Performance:
• The area under the ROC curve is 0.69.
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