A continuous infusion started after a bolus dose will reach a certain plasma concentration after a number of drug half-lives.
Parameters:
(1) concentration of the drug at steady state
(2) peak concentration of the drug after the bolus dose
number of drug half-lives required to reach a target drug concentration in plasma =
= (-1.44) * LN(((target drug concentration) - (concentration at steady state)) / ((peak concentration after the bolus) - (concentration at steady state)))
where:
• The target steady state concentration for the infusion is calculated above.
• An assumption is that the time of the bolus and the time of starting the infusion are the same.
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