NSP Score of Zhang et al for Evaluating a Patient with Intermediate Stage Hepatocellular Carcinoma

Description

Zhang et al reported NSP score for evaluating a patient with intermediate stage hepatocellular carcinoma. This can help to identify a patient who may benefit from tumor resection. The authors are from Sun Yat-sen University, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Southern Medical University and the Chinese University of Hong Kong.

Patient selection: intermediate-stage hepatocellular carcinoma (Barcelona Clinic Liver Cancer B, BCLC-B) following hepatic resection, Child-Pugh class A, age 19 to 75 years

Exclusion: platelet count < 50,000 per µL, Child-Pugh class B or C, palliative tumor resection

Outcome: overall survival

Parameters:

(1) N (number of tumors)

(2) S (size in centimeter of largest tumor diameter)

(3) P (prothrombin time in seconds, method and reference range not given)

Parameter	Finding	Points
number of tumors	1 to 3	0
	4 or more	2
tumor size	< 6 cm	0
	6 to 9 cm	1
	> 9 cm	2
prothrombin time	<= 12 seconds	0
	> 12 seconds	1

total score =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the wore the survival.

Total Score	Median Overall Survival
0 or 1	61 months
2 to 5	19 months

Performance:

• The area under the ROC curve for 1 year survival is 0.69.

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NSP Score of Zhang et al for Evaluating a Patient with Intermediate Stage Hepatocellular Carcinoma

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