Tawfik et al used nuclear grade and a proliferation index to develop the N+P scheme for grading invasive breast carcinoma. The authors are from Kansas University.
Parameters:
(1) nuclear grade
(2) MIB-1 staining (an anti-Ki-67 antibody serving as a proliferation index)
|
Parameter |
Finding |
Points |
|
nuclear grade |
small, regular, uniform (little variation in size and shape) |
1 |
|
|
moderate variation in size and shape |
2 |
|
|
marked variation in size and shape |
3 |
|
MIB-1 staining |
< 10% |
1 |
|
|
10 - 25% |
2 |
|
|
> 25% |
3 |
where:
• The authors used an automated system to determine the percent MIB-1 staining.
|
Nuclear Grade |
MIB-1 Staining |
Grade |
|
1 or 2 |
1 or 2 |
1 |
|
1 or 2 |
3 |
2 |
|
3 |
1 or 2 |
2 |
|
3 |
3 |
3 |
|
Nuclear Grade 3 |
MIB-1 Staining > 25% |
Grade |
|
Yes |
Yes |
3 |
|
No |
Yes |
2 |
|
Yes |
No |
2 |
|
No |
No |
1 |
Overall survival was similar for Grades 2 and 3 over the first 12 years after diagnosis, so the 2 can be combined.
|
Grade |
Survival at 12 Years |
|
1 |
86% |
|
2 or 3 |
66% |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
