Rosenberg et al developed a risk score for detecting nosomial sepsis in a preterm infant from a low-resource setting. The authors are from the Johns Hopkins University in Baltimore.


Patient selection: preterm infant <= 33 weeks gestation


Clinical signs:

(1) pallor

(2) apnea

(3) hepatomegaly

(4) jaundice

(5) lethargy


The presence of one or more of these clinical signs was associated with sepsis.



• The sensitivity was 77%.

• The area under the ROC curve was 70%. The positive predictive value is 65%.

• The test can be used for clinical screening, but in light of the sensitivity additional testing would be needed to find all septic patients.


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