Blue sclerae can occur with genetic and nongenetic/acquired conditions. An acquired cause is associated with a history of white sclerae in the past.
Disorders that may be associated with blue sclerae:
(1) acquired POEMS syndrome
(2) argyria
(3) Caplan syndrome
(4) HIV
(5) hyperhomocysteinemia
(6) iron deficiency anemia
(7) myasthenia gravis
(8) nevus of Ota
Medications associated with blue sclerae:
(1) minocycline
(2) mitoxantrone
(3) prednisone
(4) ezogabine or retigabine
