Noncirrhotic Portal Hypertension| Medical Algorithm

Are you evaluating an HIV patient who is being receiving antiretroviral therapy?

Yes

Does the patient have endoscopically documented esophageal varices?

Yes

Hepatic venous pressure gradient

mm Hg

Does the patient show cirrhosis on liver biopsy?

Yes

Does the patient have a chronic liver disease associated with cirrhosis (viral hepatitis, alcoholism, etc)?

Yes

Is there evidence of obstructive portal venopathy and/or periportal fibrosis?

Yes

Does the patient have a history of long-term exposure to didanosine (DDI) ?

Yes

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

Does the patient meet the criteria for noncirrhotic portal hypertension?

Number of findings seen in DDI-associated noncirrhotic portal hypertension

Should DDI therapy be discontinued?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
- Drug-Induced Liver Injury Diagnostic Scale
Laboratory Tests
- R-Ratio in Drug-Induced Liver Injury (DILI)
Criteria For Diagnosis
Severity, Prognosis, Stage
- Drug-Induced Liver Injury Network (DILIN) Grading Criteria
- Drug-Induced Liver Injury Diagnostic Scale

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Specialty

Objective

ICD-10

Noncirrhotic Portal Hypertension Associated with Antiretroviral Therapy

Purpose: To identify an HIV-infected patient with noncirrhotic portal hypertension associated with chronic didanosine (DDI) therapy.

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Specialty

Objective

ICD-10