Non-Hodgkin’s Lymphoma in Patients with Hepatitis C Virus (HCV)

Common types of B-cell lymphomas associated with HCV:

(1) extranodal MALT lymphoma (extranodal marginal zone B-cell)

(2) diffuse large B-cell (DLBCL)

(3) splenic lymphoma of villous lymphocytes

(4) mantle cell

Tumors may be nodal or extranodal.

Extranodal locations affected may include:

(1) liver

(2) salivary gland (parotid, other)

(3) spleen

(4) skin

(5) subcutaneous tissue (“lipoma-like” nodules)

(6) conjunctiva

(7) mucosa (stomach, oral, etc)

(8) breast

(9) thyroid gland

(10) lung

(11) central nervous system

Associations:

(1) cryoglobulinemia (with or without glomerulonephropathy)

(2) monoclonal gammopathy

(3) risk for severe hepatic injury or hepatitis flares during chemotherapy which may limit the intensity of therapy

(4) history of Sjogren’s syndrome