A patient infected with hepatitis C virus (HCV) may be at increased risk for non-Hodgkin’s lymphoma. 

Common types of B-cell lymphomas associated with HCV:

(1) extranodal MALT lymphoma (extranodal marginal zone B-cell)

(2) diffuse large B-cell (DLBCL)

(3) splenic lymphoma of villous lymphocytes

(4) mantle cell


Tumors may be nodal or extranodal.


Extranodal locations affected may include:

(1) liver

(2) salivary gland (parotid, other)

(3) spleen

(4) skin

(5) subcutaneous tissue (“lipoma-like” nodules)

(6) conjunctiva

(7) mucosa (stomach, oral, etc)

(8) breast

(9) thyroid gland

(10) lung

(11) central nervous system



(1) cryoglobulinemia (with or without glomerulonephropathy)

(2) monoclonal gammopathy

(3) risk for severe hepatic injury or hepatitis flares during chemotherapy which may limit the intensity of therapy

(4) history of Sjogren’s syndrome

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