Rose et al developed nomograms for evaluating women with locally advanced cervical cancer. One nomogram predicts the 5-year overall survival. The authors are from multiple hospitals in the United States and Canada.
Patient selection: woman with locally advanced cervical cancer, age 20 to 85 years, ECOG performance status 0 to 3, tumor size 0.5 to 35 cm in diameter
Parameters:
(1) histology
(2) method of establishing that paraortic lymph nodes are negative
(3) race/ethnicity
(4) tumor size in cm
(5) performance status
(6) FIGO stage
(7) grade
(8) pelvic lymph nodes
(9) treatment
|
Tumor Size |
Points |
|---|---|
|
<= 0.5 |
0 |
|
0.5 to 4 |
(-3.561 * (diameter)^2)) + (29.2 * (diameter)) - 11.84 |
|
4 to 20 |
(-0.106 * (diameter)^2)) + (4.755 * (diameter)) + 32.94 |
|
20 to 35 |
(-0.01437 * (diameter)^2)) + (1.669 * (diameter)) + 58.98 |
|
> 35 |
NA |
|
Parameter |
Finding |
Points |
|---|---|---|
|
histology |
squamous |
0 |
|
|
adenocarcinoma |
18.8 |
|
|
adenosquamous |
18.8 |
|
negative para-aortic lymph nodes |
by pathology |
0 |
|
|
by radiography |
26 |
|
performance status |
0 |
0 |
|
|
1 |
16.9 |
|
|
2 or 3 |
41.1 |
|
FIGO stage |
IB |
0.73 |
|
|
IIA |
0 |
|
|
IIB |
17.8 |
|
|
IIIA |
93.5 |
|
|
IIIB |
54.1 |
|
|
IVA |
72.6 |
|
pelvic lymph nodes |
negative or unknown |
0 |
|
|
positive |
30.5 |
|
treatment |
cisplatin plus radiation |
0 |
|
|
other chemotherapy plus radiation |
32.5 |
|
race/ethnicity |
Asian |
0 |
|
|
Hispanic |
14 |
|
|
White |
35.2 |
|
|
Black |
49.5 |
|
|
other |
49 |
|
grade |
not graded |
0 |
|
|
good |
2.9 |
|
|
moderate |
9.5 |
|
|
poor |
24.5 |
total score =
= SUM(points for all 9 parameters)
Interpretation:
• minimum score: 0
• maximum score: 416
• The higher the score the worse the 5-year overall survival.
|
Score |
Probability of 5-Year Overall Survival |
|---|---|
|
< 63 |
> 87% |
|
63 to 284 |
(-0.000679 * ((points)^2)) - (0.1281 * (points)) + 99.1 |
|
> 284 |
< 10% |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
