Fakhry et al reported 2 nomograms for predicting outcomes for a patient with oropharyngeal cancer. One model predicts progression-free survival (PFS). The authors are from Johns Hopkins University.
Patient selection: oropharyngeal cancer, ECOG 0 or 1
Parameters:
(1) p16 status
(2) Zubrod/ECOG performance status
(3) T stage (T2, T3, T4)
(4) N stage (AJCC 8th edition)
(5) age in years
(6) number of pack years for cigarette smoking
(7) education
(8) percent weight loss in the past 6 months
(9) marital status
Parameter
Finding
Points
p16 status and Zubrod status
p16 positive, Zubrod 0
0
p16 positive, Zubrod 1
84.6
p16 negative, Zubrod 0
96
p16 negative, Zubrod1
100
T stage
T2 or T3
0
T4
29.9
N stage
N0 or N1
0
N2 or N3
77.8
age in years
<= 50 years
0
> 50 years
65.2
pack years
<= 10
0
> 10
49.5
education
high school or less
45.4
post high school
0
weight loss
< 5%
0
>= 5%
39.1
marital status
partner
0
no partner
36.3
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 527.8
• The higher the score the worse the overall survival.
