Cao et al reported nomograms to predict survival of a patient with a gastric neuroendocrine carcinoma (NEC). The authors are from Fujian Medical University in China.
Patient selection: gastric neuroendocrine neoplasm
Parameters:
(1) lymph node ratio (LNR, lymph nodes with metastases to total lymph nodes)
(2) Ki-67 index
(3) tumor-associated neutrophil to lymphocyte ratio (TA NLR) using immunostains to identify neutrophils and lymphocytes within sections of the tumor
Parameter
Finding
Points for 5-Year Recurrence Free Survival
Points for 5-Year Overall Survival
LNR
0
0.01 to 0.2
5.1
4.8
0.21 to 0.4
6.4
6
> 0.4
10
Ki-67 index
<= 2
3 to 20
1.3
> 20
6.9
7.7
TA NLR
<= 0.21
> 0.21
4.7
4.3
total score for RFS =
= SUM(points for 3 parameters)
total score of OS =
Interpretation:
• minimum scores: 0
• maximum score for RFS: 21.6
• maximum score for OS: 22
RFS Score
5-Year Recurrence Free Survival
< 2.56
> 95%
2.56 to 13.38
(-0.3443 * ((score)^2)) + (1.4073 * (score)) + 93.305
13.38 to 21.44
(0.5308 * ((score)^2)) - (24.66 * (score)) + 285.3
> 21.44
< 1%
OS Score
5-Year Overall Survival
< 1.12
1.12 to 12.96
(-0.02885 * ((score)^3)) + (0.343 * ((score)^2)) - (3.333 * (score)) + 98.039
12.96 to 21.76
(0.39508 * ((score)^2)) - (19.389 * (score)) + 235.45
> 21.76
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Specialty: Hematology Oncology
