Patient selection: Chinese male
Parameters:
(1) age in years from 45 to 80
(2) volume of the prostate in mL, from 10 to 100
(3) prostate health index (PHI) based on p2PSA ([-2]proPSA), from 10 to 75
PHI =
= (p2PSA) / (free PSA) * SQRT(PSA)
points for age =
= (1.22857 * (years)) - 55.2857
points for prostate volume =
= (-0.14778 * (volume)) + 14.778
points for PHI =
= (1.53846 * (PHI)) - 15.3846
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 156.3
• The higher the score the greater the risk of prostate cancer.
|
Score
|
Probability of Prostate Cancer
|
|
< 78.1
|
< 10%
|
|
78.1 to 138.8
|
X = (0.072268 * (score)) - 7.8338
probability = 1/(1+EXP((-1)*X))
|
|
> 138.8
|
> 90%
|
Performance:
• The area under the ROC curve is 0.79.
