Zhong et al reported a nomogram for predicting survival for a patient with an aggressive non-Hodgkins lymphoma. The includes cytokine levels as input variables. The authors are from Shanghai Jiao Tong University, Soochow University, and affiliated institutions in China.
Patient selection: diffuse large B-cell lymphoma, peripheral T-cell lymphoma, NK T-cell lymphoma
Parameters:
(1) serum IL-2 receptor, from 0 to 8,000 U/mL
(2) serum TNF-alpha, from 0 to 140 pg/mL
(3) lymphocyte to monocyte ratio (LMR)
(4) serum LDH relative to the upper limit of normal (ULN)
points for serum IL-2 receptor =
= (0.0003125 * (sIL-2R))
points for serum TNF-alpha =
= (0.071428 * (TNFalpha))
Parameter
|
Finding
|
Points
|
LMR
|
<= 2.7
|
3.1
|
|
> 2.7
|
0
|
serum LDH
|
<= ULN
|
0
|
|
> ULN
|
4.6
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 20.2
value of X =
= (-0.007576 * ((score)^2)) - (0.105 * (score)) + 2.537
probability of 4-year overall survival =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve varies with the type of lymphoma.