Xia et al reported a nomogram for predicting the risk of a citrate reaction in a patient with a solid tumor undergoing apheresis to collect mononuclear cells to prepare for CAR T-cell therapy. The authors are from Shanghai University and Naval Medical University in Shanghai.
Patient selection: advanced solid tumor
Procedure: apheresis to collect mononuclear cells prior to CAR T-cell therapy
Parameters:
(1) sex of the patient
(2) age of the patient from 15 to 85 years
(3) processed blood volume in mL, from 2,000 to 8,500
points for age =
= 68.729 - (0.809 * (age))
points for blood volume =
= (0.01538 * (volume)) - 30.769
|
Sex
|
Points
|
|
male
|
0
|
|
female
|
66.44
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 223.07
value of X =
= (0.0569 * (score)) - 5.563
probability of citrate reaction =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC cuve is 0.80.
