Wu et al reported a nomogram for predicting lymphatic infiltration in colorectal cancer. The presence of lymphatic infiltration may influence the therapy that the patient receives. The authors are from Guangxi University and Guangxi Clinical Research Center for Colorectal Cancer in China.
Patient selection: colorectal cancer
Parameters:
(1) tumor differentiation
(2) CT N stage
(3) serum CEA in µg/L
(4) serum CA 19-9 in kU/L (U/mL)
points for CEA =
= (0.07 * (CEA))
points for CA 19-9 =
= (0.025 * (CA19-9))
Parameters
Finding
Points
differentiation
well-differentiated
0
moderately differentiated
2
poorly differentiated
11
N stage
N0
0
N1
11
N2
15
where:
• The nomogram is numbered 1, 2 and 3 for N stage, but Table 1 reports N0, N1 and N2.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 168
• The higher the score the more likely that lymphatic infiltration is present.
value of X =
= (0.1151 * (X)) - 1.908
probability of lymphatic invasion =
= 1 / (1 + EXP((-1) * X))
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