Winter et al reported a nomogram for predicting sentinel lymph node involvement in a patient with prostate cancer. This can help guide patient management. The authors are from Georg-August University Gottingen, Klinikum Oldenburg, Carl von Ossietzky University and Institute of Pathology Odenburg.
Patient selection: prostate cancer
Method of sentinel lymph node detection: radioisotope
Parameters:
(1) serum PSA in ng/mL
(2) clinical stage
(3) Gleason score
Parameter
Finding
Points
serum PSA
<= 4
0
4.01 to 10
1.5
10.01 to 20
19
> 20
25
clinical stage
1c
0
2
19.5
3
29
Gleason score
<= 6
0
7
24
8 to 10
46
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 100
• The higher the score the greater the risk of lymph node metastases.
X =
= (0.055005 * (score)) - 3.5123
probability of sentinel lymph node metastasis =
= 1 / (1+EXP((-1) *X))
Performance:
• The area under the ROC curve is 0.82.
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