Nomogram of Wang et al for Predicting Survival of a Patient with Acute Myeloid Leukemia (AML) Receiving Chemotherapy

Description

Wang et al reported an immune risk score for predicting survival of a patient with acute myeloid leukemia (AML) who is receiving chemotherapy. This can help to identify a patient who may require more aggressive management. The authors are from multiple institutions in China and Europe.

Patient selection: acute myeloid leukemia (AML)

Parameters:

(1) immune risk score, from -1.4 to 1.0

(2) ELN 2017 risk category

(3) age in years

points for immune risk score =

= (41.67 * (immune risk score)) + 58.33

Parameter	Finding	Points
ELN 2017 risk category	favorable	0
	intermediate	55.25
	adverse	89.63
age in years	<= 60 years	0
	> 60 years	34.81

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 224.44

value of X =

= (-0.00008243 * ((score)^2)) - (0.009926 * (score)) + 0.9968

probability of 5-year survival =

= 1/(1 + EXP((-1) * X))

Performance:

• The area under the ROC curve is 0.83.

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