Sheng et al reported a model for identify a woman with a high-grade cervical lesion. The authors are from Tongji Medical College of Huazhong University of Science and Technology in China.
Patient selection: female with gynecologic evaluation
Parameters:
(1) ThinPrep cytology test
(2) high risk HPV
(3) white acetate epithelium
(4) atypical vessels
(5) mosaic
Parameter
Finding
Points
ThinPrep
negative
0
ASCUS or AGC
25
LSIL
50
ASC-H (atypical high grade squamous cells cannot exclude HSIL)
75
HSIL or SCC
100
high risk HPV
negative
0
high risk HPV NOS
14.2
HPV16
28.5
HPV18/45
42.8
multiple
57
white acetate epithelium
no
0
yes
44.8
atypical vessels
no
0
yes
52.7
mosaic
no
0
yes
20.4
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 274.9
value of X =
= (0.02705 * (score)) - 4.143
risk of high-grade cervical lesion =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.85.
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