Rouzier et al developed a nomogram for predicting the probability of being free from distant metastases 5 or 10 years after preoperative anthracycline chemotherapy and surgery for breast cancer. This can help advise patients about outcome following this form of management. The authors are from University of Texas Houston M.D. Anderson Cancer Center, Institut Gustave Roussy in Villejuif, and Hotel-Dieu in Beirut.
Parameters:
(1) size of residual tumor at surgery in mm
(2) number of axillary lymph nodes show metastases at surgery
(3) histologic grade of the tumor
(4) estrogen receptor status
(5) histologic type
|
Parameter |
Finding |
Points |
|
histologic grade |
Grade 1 |
0 |
|
|
Grade 2 |
18 |
|
|
Grade 3 |
36 |
|
estrogen receptor status |
positive |
0 |
|
|
negative |
27 |
|
histologic type |
lobular |
0 |
|
|
ductal |
36 |
points for residual size =
= MAX(0,(0.4389 * (maximal diameter in mm)) - 0.2409)
|
Number of Positive Nodes |
Points |
|
0 |
0 |
|
1 |
16.25 |
|
> 1 |
(0.000028 * ((total score)^3)) - (0.01271 * ((total score)^2)) + (1.006 * (total points)) + 68.01 |
total score =
= SUM(points for all 5 parameters)
Probabilities of being free of distant metastases at 5 or 10 years
|
Total Score |
Probability at 5 years |
|
< 53 |
> 90% |
|
53 - 173 |
(0.000028 * ((total score)^3)) - (0.01271 * ((total score)^2)) + (1.006 * (total points)) + 68.01 |
|
> 173 |
< 10% |
|
Total Score |
Probability at 10 Years |
|
< 25 |
> 90% |
|
25 - 145 |
(0.000035 * ((total score)^3)) - (0.01202 * ((total score)^2)) + (0.4769 * (total points)) + 84.77 |
|
> 145 |
< 10% |
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
